* General toxicology : single-dose toxicity study/multiple-dose toxicity study/dose range exploration or maximum tolerated dose study
* Development and reproductive toxicology : fertility and early embryonic development toxicity test (section I-rat) / Embryo-fetal developmental toxicity test (section II - rats and rabbits) / Perinatal toxicity test (section III - rat)
* Genotoxicity : Screening of exogenous chemicals / Ames test / In vitro chromosomal aberration test / Mouse bone marrow Micronucleus test
* Immunotoxicity : tissue cross-reaction/immunogenicity, anti-drug antibody and neutralizing antibody detection/immunophenotyping analysis/T cell-dependent antibody response
* Irritation, allergy, hemolysis test : stimulation test (vascular , muscles, eyes, skin)/active allergy test/passive allergy test/in vitro hemolysis test