Methods

Rat/ Mouse/ Dog

Ovariectomy-Induced Osteoporosis

Rat/ Mouse

Retinoic Acid-Induced Osteoporosis

Methods

Rat/ Rabbit/Dog

Combined anterior and posterior cruciate ligament transection with medial meniscus removal

Mouse

DMM (Destabilization of the Medial Meniscus) model for inducing osteoarthritis in mice

Rat/Mouse/Rabbit

Collagenase-Induced Osteoarthritis

Methods

Rat/Mouse/Rabbit

Collagen-Induced Arthritis (CIA) Animal Model

Rat/Mouse/Rabbit

Adjuvant-Induced Arthritis (AA) Model

Methods

Chicken/Rat/Rabbit

Various animal models of femoral head necrosis, including traumatic, alcoholic, and steroid-induced femoral head necrosis, can be prepared according to specific experimental requirements.

Methods

Rat/Rabbit/Dog

Bone defect animal models, such as those involving skull or jawbone defects, can be prepared according to specific experimental needs.

Methods

Rat/Mouse/Rabbit

Open Fracture
An open fracture refers to a condition where the skin or mucous membrane near the fracture site is broken, resulting in the fracture ends being exposed to the external environment, either directly or indirectly. The procedure for creating an open femoral fracture model typically involves anesthetizing the mouse, followed by an incision in the skin and subcutaneous tissue of the thigh. This incision allows for blunt dissection to separate the tissue from the femoral shaft, thereby fully exposing the femur. Subsequently, tools such as an electric oscillating saw are used to make precise cuts in the bone, selecting specific angles and positions to induce the fracture.

Closed Fracture
A closed fracture is defined as a fracture where the overlying skin or mucous membrane remains intact, preventing the fracture ends from communicating with the external environment. The process involves four main components: the overall framework, animal fixation device, cutting and hammering apparatus, and weights. During the procedure, the animal is first secured in the framework. Then, weights are allowed to drop freely, utilizing the hammering device to induce a fracture at the designated location.

Methods

Rat/Mouse

Mouse osteosarcoma cell transplantation